A spatial model of autophosphorylation of Ca2+/calmodulin-dependent protein kinase II in a glutamatergic spine reveals dynamics of kinase activation in the first several seconds after a complex synaptic stimulus

Introduction

Provided here are the data and software described in the article entitled "A spatial model of autophosphorylation of Ca2+/calmodulin-dependent protein kinase II in a glutamatergic spine reveals dynamics of kinase activation in the first several seconds after a complex synaptic stimulus.", published in Frontiers in Synaptic Neuroscience here: https://www.frontiersin.org/articles/10.3389/fnsyn.2025.1547948. This archive is also available at https://doi.org/10.5281/zenodo.12764450

Downloads

MCell Model and Movie Files

The MOV file CaMKII_multiburst_color.mov contains the Supplemental movie file to accompany the article.

The PDF file CaMKII_multiburst_color_caption.pdf contains the caption explaining the movie file.

The gzipped tar file spatial_camkii_models.tar.gz contains the MCell model files described in the article.

There are 8 model files in the tar.gz file:

spine_camkii_model_cam_nontrapping_pp1_nonblocking.blend

spine_camkii_model_cam_nontrapping_pp1_blocking.blend

spine_camkii_model_cam_trapping_pp1_nonblocking.blend

spine_camkii_model_cam_trapping_pp1_blocking.blend

spine_camkii_model_psd_capsule_cam_trapping_pp1_nonlocalized_pp1_cam_nonblocking.blend

spine_camkii_model_psd_capsule_cam_trapping_pp1_nonlocalized_pp1_cam_blocking.blend

spine_camkii_model_psd_capsule_cam_trapping_pp1_localized_pp1_cam_nonblocking.blend

spine_camkii_model_psd_capsule_cam_trapping_pp1_localized_pp1_cam_blocking.blend

and other files:

README.txt

directory: glu_release_times_stp_5at50Hz_5at2Hz_2x

(Contains data used to configure models as shown in Figure 3)