MCell: A Monte Carlo Simulator of Cellular Microphysiology
Long-term potentiation expands information content of hippocampal dentate
gyrus synapses
Introduction
Segments of reconstructed dendrites in the Middle Molecular Layer of Dentate
Gyrus analyzed for presynaptic connectivity (solid yellow) revealed that most
of the axons (green) made synapses with just one dendritic spine. However,
occasionally an axon (white) made synapses with two of the dendritic spines
(blue); these are referred to as same dendrite/same axon (SDSA) pairs. The
similarity of the spine head volumes of these pairs was influenced by activity
and was less than previously observed in Area CA1. [Scale cube 1 μm3]
The gzipped tar file dentate-gyrus-spine-analysis-2018-1.tar.gz
contains the output text files from Blender Reconstructions of EM Data +
accompanying Python analysis scripts. For more details about how the data were
collected and analyzed, please refer to the
article.
To extract the contents of gzipped tar file, issue the command:
tar zxvf dentate-gyrus-spine-analysis-2018-1.tar.gz which will create a folder named
dentate-gyrus-spine-analysis-2018-1 in the current directory.